Design, synthesis, and properties of a photoactivatable membrane-spanning phospholipidic probe

…, SL Schreiber, FM Richards

Index: Delfino, Jose M.; Schreiber, Stuart L.; Richards, Frederic M. Journal of the American Chemical Society, 1993 , vol. 115, # 9 p. 3458 - 3474

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Citation Number: 75

Abstract

Abstract: We introduce here a new photochemical probe suitable for labeling deep into the hydrophobic core of membranes: bis-phosphatidylethanolamine (trifluoromethy1) phenyldiazirine 19 (DIPETPD). This is a bipolar phospholipid provided with a covalently bonded chain designed to span the membrane and equipped with a centrally defined attachment point for the photolabeling group (trifluoromethy1) phenyldiazirine (TPD). This ...