Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors

J Dudash, X Zhang, RE Zeck, SG Johnson…

Index: Dudash Jr., Joseph; Zhang, Xiaoyan; Zeck, Roxanne E.; Johnson, Sigmond G.; Cox, Geoffrey G.; Conway, Bruce R.; Rybczynski, Philip J.; Demarest, Keith T. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5121 - 5125

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Citation Number: 52

Abstract

A series of glucose conjugates was synthesized and tested for inhibition of SGLT1 and SGLT2. The core structure was derived from compound 1a. Modification of the benzofuran moiety and 4′-substituent of the phenyl ring in compound 1a improved selectivity at ...