Palladium-catalyzed cross-coupling reaction of homoallylic or homopropargylic organozincs with alkenyl halides as a new selective route to 1, 5-dienes and 1, 5- …

E Negishi, LF Valente, M Kobayashi

Index: Negishi, Ei-ichi; Valente, Louis F.; Kobayashi, Makoto Journal of the American Chemical Society, 1980 , vol. 102, # 9 p. 3298 - 3299

Full Text: HTML

Citation Number: 356

Abstract

2 pling has been achieved in most cases by the Biellmann and related allyl-allyl coupling reactions.'While these reactions appear well suited for synthesizing 1, 5-dienes represented by 1, their application to the synthesis of 2 is often complicated by regiochemical scrambling and other side rea~ tions.~ Our recent development of a highly stereoselective method for converting terminal acetylenes into various (E)-P-niethyl-1-alkenyl derivatives4 prompted ...