… ??Catalyzed Three??Component Tandem Cyclization Reaction of 2??(2, 3??Allenyl) acylacetates, Organic Halides, and Amines: An Effective Protocol for the Synthesis of 4 …

J Cheng, X Jiang, C Zhu, S Ma

Index: Cheng, Jiajia; Jiang, Xuefeng; Zhu, Can; Ma, Shengming Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1676 - 1682

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Citation Number: 19

Abstract

Abstract A domino three-component reaction of 2-(2′, 3′-allenyl) acylacetates with aryl or alkenyl halides and aryl-or benzylamines afforded 4, 5-dihydro-1H-pyrrole derivatives highly chemo-and regioselectively in one pot through imine formation/imine-enamine tautomerization under the catalysis of palladium (0) and toluenesulfonic acid monohydrate. A high diastereoselectivity was observed.