Potent anti-muscarinic activity in a novel series of quinuclidine derivatives

…, A Wagner, C Mioskowski, R Massingham…

Index: Starck, Jean-Philippe; Talaga, Patrice; Quere, Luc; Collart, Philippe; Christophe, Bernard; Brutto, Patrick Lo; Jadot, Sophie; Chimmanamada, Dinesh; Zanda, Matteo; Wagner, Alain; Mioskowski, Charles; Massingham, Roy; Guyaux, Michel Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 373 - 377

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Citation Number: 8

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and biological evaluation of a novel family of M 3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties. ... The synthesis and biological ...