Journal of medicinal chemistry

Design of cancer-specific antitumor agents based on aziridinylcyclopent [b] indoloquinones

C Xing, P Wu, EB Skibo, RT Dorr

Index: Xing, Chengguo; Wu, Ping; Skibo, Edward B.; Dorr, Robert T. Journal of Medicinal Chemistry, 2000 , vol. 43, # 3 p. 457 - 466

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Citation Number: 29

Abstract

The merits of N-unsubstituted indoles and cyclopent [b] indoles as DNA-directed reductive alkylating agents are described. These systems represent a departure from N-substituted and pyrrolo [1, 2-a]-fused systems such as the mitomycins and mitosenes. The cyclopent [b] indole-based aziridinylquinone system, when bearing an acetate leaving group with or without an N-acetyl group, was cytotoxic and displayed significant in vivo activity against ...