Mechanistic Insights into the One??Pot Synthesis of Propargylamines from Terminal Alkynes and Amines in Chlorinated Solvents Catalyzed by Gold Compounds and …

…, M Contel, EP Urriolabeitia

Index: Aguilar, David; Contel, Maria; Urriolabeitia, Esteban P. Chemistry - A European Journal, 2010 , vol. 16, # 30 p. 9287 - 9296

Full Text: HTML

Citation Number: 50

Abstract

Abstract Propargylamines can be obtained from secondary amines and terminal alkynes in chlorinated solvents by a three-and two-component synthesis catalyzed by gold compounds and nanoparticles (Au-NP) under mild conditions. The use of dichloromethane allows for the activation of two C [BOND] Cl bonds and a clean transfer of the methylene fragment to the final product. The scope of the reaction as well as the influence of different gold (III) ...