A novel palladium system for an intermolecular addition of formamides to alkynes has been developed. The reaction of formamides with internal alkynes in the presence of a palladium catalyst with acid chloride as an additive afforded (E)-α, β-unsaturated amides regio-and stereoselectively. The same catalyst system realized the first example of the addition of formamides to terminal alkynes giving the corresponding α, β-unsaturated amides bearing ...
