Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

Y Hamada, HD Tagad, Y Nishimura, S Ishiura…

Index: Hamada, Yoshio; Tagad, Harichandra D.; Nishimura, Yoshinori; Ishiura, Shoichi; Kiso, Yoshiaki Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1130 - 1135

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Citation Number: 14

Abstract

Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of non-peptidic BACE1 inhibitors. Although these peptidic and non-peptidic inhibitors, with a ...