J. Am. Chem. Soc

Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis

G Wang, MJ Krische

Index: Crimmins, Michael T.; Vanier, Grace S. Organic Letters, 2006 , vol. 8, # 13 p. 2887 - 2890

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Abstract

... of unsaturated alcohol 7 with crotonaldehyde in the presence of substoichiometric quantities of (S)-camphorsulfonic acid using the second-generation Hoveyda–Grubbs catalyst occurs with spontaneous oxa-Michael cyclization to furnish the 2,6-disubstituted pyran 8 as a single ...