Bioorganic & medicinal chemistry

Novel irreversible butyrylcholinesterase inhibitors: 2-chloro-1-(substituted-phenyl) ethylphosphonic acids

N Zhang, JE Casida

Index: Zhang, Nanjing; Casida, John E Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1281 - 1290

Full Text: HTML

Citation Number: 28

Abstract

2-Chloroethylphosphonic acid (ethephon) as the dianion phosphorylates butyrylcholinesterase (BChE) at its active site. In contrast, the classical organophosphorus esterase inhibitors include substituted-phenyl dialkylphosphates (eg, paraoxon) with electron-withdrawing aryl substituents. The chloroethyl and substituted-phenyl moieties are combined in this study as 2-chloro-1-(substituted-phenyl) ethylphosphonic acids (1) to ...