Journal of the American Chemical Society

The mechanism of action of coenzyme B12. The role of thioester in a nonenzyme model reaction for coenzyme B12 dependent isomerization of methylmalonyl …

AI Scott, K Kang

Index: Scott,A.I.; Kang,K. Journal of the American Chemical Society, 1977 , vol. 99, p. 1997 - 1999

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Citation Number: 36

Abstract

Although much interest has been focused on the search for a mechanistic rationale for the biological reactions of adenosylcobalamin,'little parallel exists in organic chemistry for many of the processes involved. The evolution of working, nonenzymic models to uncover the requisite analogies has already led to some suggestive experiments2 In the case of the methylmalonyl CoA e succinyl CoA (I $11) conversion, such a model in its most ...