Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene

WL Albrecht, RW Fleming, SW Horgan…

Index: Albrecht; Fleming; Horgan; Mayer Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 364 - 371

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Citation Number: 26

Abstract

A series of bisalkamine esters, bis-basic ethers, and bis-basic ketones of carbazole, N- ethylcarbazole, dibenzofuran, and dibenzothiophene was synthesized and evaluated for antiviral activity. The series also included two bis-basic alkanes of N-ethylcarbazole and one bis-basic carboxamide of dibenzofuran. Structureactivity relationships indicated that within the carbazole and N-ethylcarbazole series the bisalkamine esters gave the most active ...