Hydraphile channels: structural and fluorescent probes of position and function in a phospholipid bilayer

E Abel, GEM Maguire, O Murillo, I Suzuki…

Index: Abel, Ernesto; Maguire, Glenn E. M.; Murillo, Oscar; Suzuki, Iwao; De Wall, Stephen L.; Gokel, George W. Journal of the American Chemical Society, 1999 , vol. 121, # 39 p. 9043 - 9052

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Citation Number: 70

Abstract

Three novel tris (macrocycle) s having fluorescent residues at their distal termini have been prepared and studied. The compounds are of the form R〈 N18N∟ C12〈 N18N∟ C12〈 N18N∟ R in which R is 2-(3-indolyl) ethyl (1), 2-(3-(N-methylindolyl)) ethyl (2), and dansyl (3). Compounds 2 and 3 were found to transport Na+ at rates similar to those of other tris (macrocyclic) s but 1 was not an ionophore in the bilayer as assessed by 23Na NMR ...