Efficient in??loop synthesis of high specific radioactivity [11C] carfentanil

AR Studenov, S Jivan, KR Buckley…

Index: Studenov, Andrei R.; Jivan, Salma; Buckley, Kenneth R.; Adam, Michael J. Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 9 p. 837 - 842

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Citation Number: 17

Abstract

Abstract The synthesis of the precursor for [11 C] carfentanil and the precursor labelling with 11 C have both been improved. The problem 'bottleneck'step in the carfentanil precursor synthesis, due to low chemical yield (14%) of intermediates nitrile into amide conversion, has been solved. Application of a H 2 O 2/K 2 CO 3/DMSO reaction method significantly increased the yield of this chemical transformation (up to 84%). A simple and straight- ...