Preparation and Structure-Activity Relationships of Novel Asterriquinone Derivatives.

A Kaji, K Kimura, M Teranishi, N KIRIYAMA…

Index: Kaji, Akira; Kimura, Kengo; Teranishi, Masanori; Kiriyama, Noriki; Nomura, Masaaki; Miyamoto, Ken-Ichi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1325 - 1329

Full Text: HTML

Citation Number: 12

Abstract

Asterriquinone (ARQ, 1a) is an antitumor metabolite of Aspergillus terreus IFO 6123. To gain insight into the structure-activity relationships of ARQ, a series of chemically modified derivatives (1-6), the ARQ analogues (be) and the 2, 5-dihydroxy-p-bezoquinone analogues (fh), were prepared, and cytotoxic acitivity against mouse leukemia P388 cells investigated. Results indicated that: 1) at least one hydroxy group or acetoxy group in the p- ...

 Related Synthetic Route
N/A Structure

160786-85-6

N/A

~%

2,5-Bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-2,5-cyclohexadiene-1,4-dione Structure

60924-75-6

2,5-Bis[1-(1,1-...

2,5-Cyclohexadiene-1,4-dione, 2,5-bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy- Structure

60696-52-8

2,5-Cyclohexadi...

~%

2,5-Bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-2,5-cyclohexadiene-1,4-dione Structure

60924-75-6

2,5-Bis[1-(1,1-...

4-methoxy-2,5-bis(1-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)-3,6-dioxocyclohexa-1,4-dien-1-yl acetate Structure

173348-60-2

4-methoxy-2,5-b...

~%

2,5-Bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-2,5-cyclohexadiene-1,4-dione Structure

60924-75-6

2,5-Bis[1-(1,1-...

N/A Structure

173348-64-6

N/A

~%

2,5-Bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-2,5-cyclohexadiene-1,4-dione Structure

60924-75-6

2,5-Bis[1-(1,1-...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved