Kinetic studies of Micrococcus luteus BP 26 undecaprenyl diphosphate synthase reaction using 3-desmethyl allylic substrate analogs

K Fujikura, Y Maki, N Ohya, M Satoh…

Index: Fujikura, Keitaro; Maki, Yuji; Ohya, Norimasa; Satoh, Mikiya; Koyama, Tanetoshi Bioscience, Biotechnology and Biochemistry, 2008 , vol. 72, # 3 p. 851 - 855

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Citation Number: 5

Abstract

In order to investigate the substrate binding feature of undecaprenyl diphosphate synthase from Micrococcus luteus BP 26 with respect to farnesyl diphosphate and a reaction intermediate,(Z, E, E)-geranylgeranyl diphosphate, we examined the reactivity of artificial substrate analogs, 3-desmethyl farnesyl diphosphate and 3-desmethyl Z-geranylgeranyl diphosphate, which lack the methyl group at the 3-position of farnesyl diphosphate and Z- ...