Tetrahedron letters

Cyclopropanation of 3, 4-dihydro-1 H-benzo [e][1, 4] diazepine-2, 5-diones

O Lack, RE Martin

Index: Lack, Oliver; Martin, Rainer E. Tetrahedron Letters, 2005 , vol. 46, # 47 p. 8207 - 8211

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Citation Number: 15

Abstract

A two step parallel synthesis protocol for the preparation of 1N-substituted spirobenzodiazepineones is described. Treatment of 4-methyl-3, 4-dihydro-1H-benzo [e][1, 4] diazepine-2, 5-dione with a series of alkyl halides using a microwave-assisted heating protocol provided N-derivatized compounds, which were transformed to the corresponding cyclopropylamines employing modified Kulinkovich-type reaction conditions. X-ray ...