Abstract: The antifungal antibiotic griseofulvin (1) is a polyketide metabolite of Penicillium griseofuluum for which the present study has revealed that at least two and probably all three of the 0-methyl groups are introduced after both carbocyclic rings have been formed. Benzophenone 11, the monomethylated precursor predicted by earlier workers, could not be detected in cultures by carrier dilution experiments. Instead benzophenone 14 was shown ...
