(+)-Dactylolide (1, Figure1) is a cytotoxic 20-membered macrolide isolated from the Vanuatu sponge Dactylospongia sp by Riccio and co-workers.[1] It possesses unique structural features which include a 2, 6-cis-2-(4-oxo-2-butenyl) tetrahydropyran, a highly unsaturated 20-membered macrolactone, and an a-chiral aldehyde.(+)-Dactylolide (1) displayed modest tumor cell growth inhibitory activities in leukemia and ovarian cancer cell lines [1] and the ...
