Synthesis and biological activity of 3-and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone

…, TS Lin, JG Cory, AH Cory, AC Sartorelli

Index: Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C. Synthetic Communications, 1990 , vol. 20, # 19 p. 2965 - 2970

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Citation Number: 71

Abstract

A series of 3-and 5-alkylamino derivatives, as well as other structurally modified analogues of pyridine-2-carboxaldehyde thiosemicarbazone, have been synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vitro and antineoplastic