Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: Investigations on 3-carboalkoxy-2-methyl-2, 3-dihydro-1H-phenothiazin-4 [10H]-one …

ML Laws, RR Roberts, JM Nicholson, R Butcher…

Index: Laws, Mia L.; Roberts, Ralph R.; Nicholson, Jesse M.; Butcher, Raymond; Stables, James P.; Goodwin, Angela M.; Smith, Carlynn A.; Scott Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2289 - 2299

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Citation Number: 24

Abstract

A new series of anticonvulsant 3-carboalkoxy-2-methyl-2, 3-dihydro-1H-phenothiazin-4 [10H]-ones is herein reported. 2-Aminothiophenols underwent cyclocondensation with 4- carboalkoxy-5-methylcyclohexane-1, 3-diones in refluxing dimethylsulfoxide (DMSO) to yield 3-carboalkoxy-2-methyl-2, 3-dihydro-1H-phenothiazin-4 [10H]-ones, 4a–k. In the case of the carbo-tert-butoxy derivatives (4c and 4k) prolonged reaction times led to the ...