Methotrexate analogs. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids

A Rosowsky, H Bader, W Kohler…

Index: Rosowsky; Bader; Kohler; Freisheim; Moran Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1338 - 1344

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Citation Number: 11

Abstract

Methods: A= DEPC coupling; B= mixed carboxylic-carbonic anhydride coupling; C= nitrophenyl ester displacement; D= alkaline hydrolysis.* TLC systems: 1= silica gel, 2: 5: 5 MeOH-MeCN-CHCl,; 2= silica gel, 1: 5: 5 MeOH-MeCN-CHCl,; 3= silica gel, 1: 5: 15 AcOH- MeOH-CHC1,; 4= silica gel, 1: 4: 5 NH4OH-MeOH-CHCl3, HPLC was carried out on a Waters CIB pBondapak column, which was eluted with 0.1 M NH40Ac, pH 6.0, containing ...