Synthesis of new 4-[2-(4-methyl (amino) sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1, 2, 3, 6-tetrahydropyridines: A search for novel nitric oxide donor anti- …

MA Chowdhury, KRA Abdellatif, Y Dong…

Index: Chowdhury, Morshed Alam; Abdellatif, Khaled R.A.; Dong, Ying; Knaus, Edward E. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8882 - 8888

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Citation Number: 24

Abstract

A group of 4-[2-(4-methyl (amino) sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1, 2, 3, 6- tetrahydropyridines (11–14) possessing a variety of substituents (Me, CO2Et, H, N= O) attached to the 1, 2, 3, 6-tetrahydropyridyl N1-nitrogen atom were synthesized and evaluated as anti-inflammatory agents. Structure–activity relationship data showed that the N-methyl-1, 2, 3, 6-tetrahydropyridyl moiety is a suitable bioisosteric replacement for the ...