1,3-Dithiane- 1 -oxide derivatives serve as chiral acyl anion equivalents for the enantioselective synthesis of a wide range of products. For example, 2-acyl-2-alkyl- 1,3-dithiane-l-oxides give highly diastereoselective enolate alkylations and amina- tions, Mannich reactions, organometallic additions, hetero- cyclic cycloadditions and so on. trans- 1,3-Dithianedioxide can be transformed into thioesters, which act as starting materials for the synthesis of esters, amines, ketones ...
[Noort, Paul C. M. van; Vermeeren, Hans P. W.; Louw, Robert Recueil: Journal of the Royal Netherlands Chemical Society, 1983 , vol. 102, # 6 p. 312 - 321]
