Studies on the formation of 14-membered macrocycles by intramolecular Michael addition

C Crévisy, M Couturier, C Dugave, YL Dory…

Index: Crevisy, Christophe; Couturier, Michel; Dugave, Christophe; Dory, Yves L.; Deslongchamps, Pierre Bulletin de la Societe Chimique de France, 1995 , vol. 132, # 4 p. 360 - 370

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Citation Number: 10

Abstract

Résumé/Abstract Intramolecular Michael addition of β-ketoesters on enones 1, 2 and 3 with two conjugated unsaturations along the connecting chain led to cyclic monomers and dimers. These reactions work best with a cis alkene; they give poor yield of monomer with a trans alkene and no monomer with an alkyne.