Novel Hypotensive Agents from Verbesina c aracasana. 8. Synthesis and Pharmacology of (3, 4-Dimethoxycinnamoyl)-N 1-agmatine and Synthetic Analogues1

…, R Espinal, SC De Bonnevaux, C De Luca…

Index: Carmignani; Volpe; Botta; Espinal; De Bonnevaux; De Luca; Corelli; Tafi; Sacco; Delle Monache Journal of Medicinal Chemistry, 2001 , vol. 44, # 18 p. 2950 - 2958

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Citation Number: 42

Abstract

The more polar metabolites from the Venezuelan plant Verbesina caracasana, ie, N 3- prenylagmatine,(3, 4-dimethoxycinnamoyl)-N 1-agmatine, agmatine, and galegine (prenylguanidine), previously reported (Delle Monache, G.; et al. BioMed. Chem. Lett. 1999, 9, 3249-3254), have been synthesized following a biosynthetic strategy. The pharmacologic profiles of various synthetic analogues of (3, 4-dimethoxycinnamoyl)-N 1-agmatine (G5) ...