Cubylcarbinol (1) has previously been prepared in three steps from commercially available dimethyl-1,4-cubane dicarboxylate (2). [9] Partial hydrolysis of 2 yields 4-methoxycarbonylcubane carboxylic acid (3) which was converted to cubanecarboxylic acid (4) via a Barton decarboxylation followed by additional hydrolysis. [9a] Reduction of 4 affords cubylcarbinol (1). [9b] The best literature preparation delivers 1 in 70% overall yield from 2. Herein, we report three ...
