e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Quinazolines. 12. 1, 3-Diaminobenzo [f] quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as …
A Rosowsky, PC Huang…
Index: Rosowsky,A. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1217 - 1222
8 9 by its prominent ir absorption at 1740 cm-l. Chemical support for structure 7 was also provided by acid hydrolysis and catalytic hydrogenation, which led successively to 8 (91%) and 9 (92%). The origin of 7 can be rationalized by assuming that the primary adduct, 3-n- heptanoyl-2-methoxynaphthalene, condenses very rapidly with 3-lithio-2- methoxynaphthalene to give an alkoxide which then reacts immediately with another ...
