Abstract 5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and allergic diseases. Here, we present the discovery and biological evaluation of novel series of 1, 4-benzoquinones and respective resorcinol derivatives that efficiently inhibit human 5-LO, with little effects on other human ...
