(.+-.)-4-Aryl-4, 5-dihydro-3H-1, 3-benzodiazepines. 2. Nuclear substituted analogs of (.+-.)-4, 5-dihydro-2, 3-dimethyl-4-phenyl-3H-1, 3-benzodiazepine and (.+-.)-4, 5- …

LL Martin, LL Setescak, M Worm…

Index: Martin; Setescak; Worm; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 346 - 351

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Citation Number: 8

Abstract

Chemistry. The synthesis of 1, 3-benzodiazepines 9a-j and loa-j is outlined in Scheme I, and their properties are summarized in Table I. Properties of the various intermediates are summarized in Tables I1 and 111. Ketones% a, b, d, e were prepared by Friedel-Crafts synthesis with 2-nitrophenylacetyl chloride. Although of good utility, this synthesis was limited by the availability of nuclear-substituted 2-nitrophenylacetic acids and by the ...