Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

…, C Pandit, R Singh, M Kully, J Khan, JJ Plattner…

Index: Baker, Stephen J.; Akama, Tsutomu; Zhang, Yong-Kang; Sauro, Vittorio; Pandit, Chetan; Singh, Rajeshwar; Kully, Maureen; Khan, Jehangir; Plattner, Jacob J.; Benkovic, Stephen J.; Lee, Ving; Maples, Kirk R. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5963 - 5967

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Citation Number: 44

Abstract

A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and-negative bacteria. Our lead compounds were then screened for anti-inflammatory activity. From these studies, we identified 3-hydroxypyridine-2-carbonyloxy-bis (3-chloro-4-methylphenyl) borane (2g, AN0128) as having the best combination of anti-bacterial and anti-inflammatory activities. ...