The 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)-propionate (AMPA) receptor mediates fast glutamatergic synaptic transmission in the central nervous system. Overactivation of AMPA receptors may play a role in epileptogenesis and glutamate-induced neuronal death. 1 Thus there is considerable interest in discovery of AMPA receptor antagonists and several classes of compounds have been identified. 2 These include compounds that competitively displace glutamate binding, ...
