Furo [2, 3??d] pyrimidines and Oxazolo [5, 4??d] pyrimidines as Inhibitors of Receptor Tyrosine Kinases (RTK)

A Martin??Kohler, J Widmer, G Bold…

Index: Martin-Kohler, Andreas; Widmer, Joerg; Bold, Guido; Meyer, Thomas; Sequin, Urs; Traxler, Peter Helvetica Chimica Acta, 2004 , vol. 87, # 4 p. 956 - 975

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Citation Number: 34

Abstract

Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new types of oxazolo [5, 4-d] pyrimidines and furo [2, 3-d] pyrimidines were synthesized (Schemes 1 and 2). Appropriately substituted derivatives of ...