New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A 2B adenosine receptor antagonists

…, J Beleta, A Cárdenas, E Lozoya, MI Cadavid…

Index: Esteve, Cristina; Nueda, Arsenio; Diaz, Jose Luis; Beleta, Jorge; Cardenas, Alvaro; Lozoya, Estrella; Cadavid, Maria Isabel; Loza, Maria Isabel; Ryder, Hamish; Vidal, Bernat Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3642 - 3645

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Citation Number: 19

Abstract

A new series of 4-(1, 3-dialkyl-2, 4-dioxo-2, 3, 4, 5-tetrahydro-1H-pyrrolo [3, 2-d] pyrimidin-6- yl) benzenesulfonamides has been identified as potent A2B adenosine receptor antagonists. The products have been evaluated for their binding affinities for the human A2B, A1 and A3 adenosine receptors. 6-(4-{[4-(4-Bromobenzyl) piperazin-1-yl] sulfonyl} phenyl)-1, 3-dimethyl-1H-pyrrolo [3, 2-d] pyrimidine-2, 4 (3H, 5H)-dione (16) showed a ...