Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly

…, M Sanville, C Leitheiser, M Christmann…

Index: Wang, Bo; Hansen, T. Matthew; Wang, Ting; Wu, Dimao; Weyer, Lynn; Ying, Lu; Engler, Mary M.; Sanville, Melissa; Leitheiser, Christopher; Christmann, Mathias; Lu, Yingtao; Chen, Jiehao; Zunker, Nicholas; Cink, Russell D.; Ahmed, Feryan; Lee, Chi-Sing; Forsyth, Craig J. Journal of the American Chemical Society, 2011 , vol. 133, # 5 p. 1484 - 1505

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Citation Number: 27

Abstract

The phorboxazole natural products are among the most potent inhibitors of cancer cell division, but they are essentially unavailable from natural sources at present. Laboratory syntheses based upon tri-component fragment coupling strategies have been developed that provide phorboxazole A and analogues in a reliable manner and with unprecedented efficiency. This has been orchestrated to occur via the sequential or simultaneous ...