The Journal of organic chemistry

Multifold bond cleavage and formation between MeOH and quinoxalines (or benzothiazoles): synthesis of carbaldehyde dimethyl acetals

Y Liu, B Jiang, W Zhang, Z Xu

Index: Liu, Yunkui; Jiang, Bo; Zhang, Wei; Xu, Zhenyuan Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 966 - 980

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Citation Number: 23

Abstract

A K2S2O8-mediated direct cross-coupling of quinoxalines (or benzothiazoles) with methanol leading to 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde dimethyl acetals has been achieved. 2-Quinoxalinyl carbaldehyde dimethyl acetals were readily converted into 2- quinoxalinyl carbaldehydes in good to excellent yields under acidic conditions. Preliminary mechanistic studies suggest that the reaction proceeds via multifold bond cleavage and ...