Tetrahedron letters

Lewis acid-mediated addition of silylated methylenecyclopropane to aldehydes—synthesis of tetrahydrofuran derivatives

L Patient, MB Berry, JD Kilburn

Index: Patient, Lee; Berry, Malcolm B.; Kilburn, Jeremy D. Tetrahedron Letters, 2003 , vol. 44, # 5 p. 1015 - 1017

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Citation Number: 50

Abstract

Methylenecyclopropane 1, with its highly strained ring and reactive exocyclic double bond, has long attracted interest as a synthetic intermediate, 1 and methylenecyclopropane derivatives have consequently been extensively used in synthesis, for example in [3+2] cycloaddition reactions catalysed by transition metals, 2 in radical based annulation reactions 3 and in radical cyclisation reactions. 4 A new aspect of methylene cyclopropane chemistry was recently revealed by ...