Synthesis and anti-inflammatory activity of acetylenic thiophenes

…, CW Nogueira, RB Panatieri, DO Silva, PH Menezes…

Index: Zeni, Gilson; Nogueira, Cristina W.; Panatieri, Rodrigo B.; Silva, Dagoberto O.; Menezes, Paulo H.; Braga, Antonio L.; Silveira, Claudio C.; Stefani, Helio A.; Rocha, Joao B.T. Tetrahedron Letters, 2001 , vol. 42, # 45 p. 7921 - 7923

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Citation Number: 54

Abstract

A series of acetylenic thiophene derivatives have been synthesized via Pd-catalyzed coupling reaction of 2-(butyltelluro) thiophene with a variety of terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenin-induced paw edema assay on rats.