Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions

…, K Yamato, JS Ferguson, B Gong

Index: Li, Minfeng; Yamato, Kazuhiro; Ferguson, Joseph S.; Gong, Bing Journal of the American Chemical Society, 2006 , vol. 128, # 39 p. 12628 - 12629

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Citation Number: 50

Abstract

Oligoamide strands that associate in a sequence-specific fashion into hydrogen-bonded duplexes in nonpolar solvents were converted into disulfide cross-linked duplexes in aqueous media. Thus, by incorporating trityl-protected thiol groups, which allows the reversible formation of disulfide bonds, into the oligoamide strands, only duplexes consisting of complementary hydrogen-bonding sequences were formed in aqueous solution as well ...