Design, synthesis and evaluation of serine protease inhibitor analogues

…, WM De Borggraeve, C Gielens, A Voet…

Index: Kamoune, Laila; De Borggraeve, Wim M.; Gielens, Constant; Voet, Arnout; Robeyns, Koen; De Maeyer, Marc; Van Meervelt, Luc; Compernolle, Frans; Hoornaert, Georges European Journal of Organic Chemistry, 2007 , # 18 p. 2977 - 2986

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Citation Number: 3

Abstract

Abstract Recent efforts in the field of thrombin inhibitor research have focused on the identification of pyrazinone-containing compounds. In this manuscript we describe the synthesis of the new pyrazinones 12–36. All the targets were fully characterised and screened for serine protease inhibition.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)