Nucleophilic substitution reaction in indole chemistry: 1-methoxy-6-nitroindole-3-carbaldehyde as a versatile building block for 2, 3, 6-trisubstituted indoles

K Yamada, F Yamada, T Shiraishi…

Index: Yamada, Koji; Yamada, Fumio; Shiraishi, Takei; Tomioka, Saori; Somei, Masanori Heterocycles, 2009 , vol. 77, # 2 p. 971 - 982

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Citation Number: 11

Abstract

抄録: 1-Methoxy-6-nitroindole-3-carbaldehyde is proved to be a versatile electrophile and reacts regioselectively at the 2-position with various types of nucleophiles providing 2, 3, 6- trisubstituted indole derivatives. The reaction is applicable for the preparation of a novel pyrimido [1, 2-a] indole derivative.© 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.