Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives

SA Galal, AS Abdelsamie, H Tokuda, N Suzuki…

Index: Galal, Shadia A.; Abdelsamie, Ahmed S.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Elhefnawi, Mahmoud M.; Ramadan, Raghda A.; Atta, Mona H.E.; El Diwani, Hoda I. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 327 - 340

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Citation Number: 28

Abstract

The reaction of o-phenylene diamine and ethyl oxamate is reinvestigated and led to 3- aminoquinoxalin-2 (1H)-one rather than benzimidazole-2-carboxamide as was previously reported. The structure of the obtained quinoxaline has been confirmed by X-ray. The anti- tumor activity of synthesized quinoxalines 1–21 has been evaluated by studying their possible inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced ...