Synthesis and in vitro anticancer activity of 6, 7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl) quinolin-4-one analogs

…, YY Cheng, CY Liu, LC Chou, LJ Huang, TS Wu…

Index: Chen, Chien-Ting; Hsu, Mei-Hua; Cheng, Yung-Yi; Liu, Chin-Yu; Chou, Li-Chen; Huang, Li-Jiau; Wu, Tian-Shung; Yang, Xiaoming; Lee, Kuo-Hsiung; Kuo, Sheng-Chu European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6046 - 6056

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Citation Number: 15

Abstract

6, 7-Methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl) quinolin-4-ones and their isosteric compounds were synthesized and evaluated for anticancer activity. Structure–activity relationships (SAR) of these compounds were established. Among all tested compounds, 6, 7-methylenedioxy-2-(5-methylselenophen-2-yl) quinolin-4-one (4d) was found to be the most promising anticancer agent. In screening against NCI's 60 ...