In continuation of our investigation of the synthesis of pyrimidine derivatives through condensation of amidines with malonic e~ ters,~*~ we have now studied the interaction of butamidine with ethyl malonate and five ethyl alkylmalonates. The 2-propyl-4, 6 (1, 5)- tetrahydropyrimidinediones thus obtained were converted into 4, 6-dichloro derivatives by treatment with phosphorus oxychloride. With the appropriate reagents and reaction ...
