Abstract The stability of 3, 5-di-tert-butylsalicylic aldehyde against oxidation is due to autoinhibiting of the chain process. However its oxidation into 3, 5-di-tert-butylsalicylic acid was performed at the use of acetyl protection of the hydroxy group. In reaction of 6-bromo-2, 4-di-tert-butylphenol with urotropin the formation was discovered of 3, 5-di-tert-butylsalicylic acid, its nitrile and amide.