Abstract Tris-(hydroxymethyl)-aminomethane reacts with various aromatic or heterocyclic aldehydes, leading to new mono-or bicyclic oxazolidine derivatives. The importance of molecular surroundings of the nitro group has been evaluated by the genotoxic study of synthetised compounds using metronidazole and dimetridazole as reference compounds.
![[2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazolidin-4-yl]methanol Structure](https://image.chemsrc.com/caspic/131/94885-38-8.png)