Chemistry letters

Synthesis of thiepin-annulated pyrone and coumarin heterocycles by Grubbs' second generation catalyst mediated enyne metathesis

KC Majumdar, S Muhuri, H Rahaman, R Islam, B Roy

Index: Majumdar; Muhuri; Rahaman; Islam; Roy Chemistry Letters, 2006 , vol. 35, # 12 p. 1430 - 1431

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Citation Number: 21

Abstract

Coumarin and 2-pyrone are important heterocyclic com- pounds because these nuclei are found in many natural prod- ucts.1 Coumarins fused with other heterocycles have interesting biological and photodynamic properties.2 Several natural3 and synthetic4 2-pyrones exhibit remarkable biological activity. Recently, we have demonstrated the synthesis of pyrone and coumarin-annulated heterocycles by the application of the Claisen rearrangement5 and radical cyclization.6 ...