Design and synthesis of novel derivatives of the muscarinic agonist tetra (ethylene glycol)(3-methoxy-1, 2, 5-thiadiazol-4-yl)[3-(1-methyl-1, 2, 5, 6-tetrahydropyrid-3-yl)- …

…, J Dorsey, M Rieman, E Lawlor, M Warrier…

Index: Tejada, Frederick R.; Nagy, Peter I.; Xu, Min; Wu, Cindy; Katz, Tricia; Dorsey, Jason; Rieman, Melissa; Lawlor, Elizabeth; Warrier, Manya; Messer Jr., William S. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7518 - 7531

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Citation Number: 17

Abstract

As part of a continuing effort to design and synthesize highly selective muscarinic agonists for different muscarinic receptor subtypes, several tetra (ethylene glycol)(3-methoxy-1, 2, 5- thiadiazol-4-yl)[3-(1-methyl-1, 2, 5, 6-tetrahydropyrid-3-yl)-1, 2, 5-thiadiazol-4-yl] ether (1) analogues were prepared and characterized. Different analogues were synthesized having hydrophilic spacers of di-, tri-, tetra-, penta (ethylene glycol) and tri (propylene glycol) ...