Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents

…, LM Abdel-Aziz, ESM Lashine, MI Husseiny…

Index: Metwally, Kamel A.; Abdel-Aziz, Lobna M.; Lashine, El-Sayed M.; Husseiny, Mohamed I.; Badawy, Rania H. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8675 - 8682

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Citation Number: 118

Abstract

A new series of 2-arylquinoline-4-carboxylic acid hydrazide–hydrazones was synthesized using an appropriate synthetic route. All the target compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus as an example for Gram-positive bacteria, Escherichia coli as an example for Gram-negative bacteria, and Candida albicans as a representative of fungi. The minimum inhibitory concentration (MIC) was determined ...